New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be ...

Measuring Enzyme Kinetic Parameters with the ITC Universal Enzyme Assay Method Enzymes are important in drug discovery and development since they constitute approximately one-half of all known drug ...

This article describes a simple method to determine the optimum pH for the activity of one enzyme in a coupled enzyme assay. Decoupling of the two-step reaction is achieved by heat denaturing the ...

People with chronic lung diseases such as cystic fibrosis are caught in a vicious circle: infections cause inflammation and immune cells rush into airways, but in the process of killing infectious ...

As a result of the introduction of these several tests, the clinician may be faced with the problem of evaluating patients whose enzyme activity has been determined by more than one method. This ...

Aging, progression, and phenotype in breast cancer. Extracts from 998 breast carcinomas were assayed for p53 protein by an ELISA that used both DO-1 monoclonal and CM-1 polyclonal antibodies. Relative ...

Volume 38 of SLAS Discovery includes one review, three original research articles, and the editorial of the recently published ...

Microbial assays are a technique to assess a compound’s potency or concentration. This is carried out by exposing microorganisms to the compound and determining its effect on them. Microbial assays ...

Cell death in vitro can be induced by several distinct mechanisms depending upon the type and potency of the stimulus. Biological variables present a challenge to rapid and efficient characterization ...