Once considered cellular junk, non-coding RNAs are emerging as key players in everything from brain development to cancer — ...

在真核生物中，由小RNA介导的基因沉默机制是保护基因组完整性、抵御转座子入侵的重要手段。然而，出现了一个逻辑上似乎自相矛盾的环节：为了沉默转座子，细胞必须先以转座子为模板，转录产生后续用于靶标转座子的RNA。如何精准识别并转录那些本应处于抑制状态的转 ...

Long non-coding RNAs exist in the so-called "Wild West" (99%) of the human genome that is currently understudied. Not only does this finding have treatment implications for patients with ...

Scientists profiling small non-coding RNAs in postmortem brain tissue from people with schizophrenia and bipolar disorder have identified sweeping molecular disruptions that extend well beyond the ...

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins—yet it exists in large quantities. A research team from ...

Terc-53 functions as a molecular scaffold bringing together Hmmr and Trim25, accelerating Hmmr’s ubiquitination-mediated degradation, which consequently leads to neuroinflammation and cognition ...

Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with night blindness in youth and progresses to tunnel vision as ...

To understand the human genome, scientists focused on protein-coding genes and their functions for decades. This has given us ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Researchers at the Icahn School of Medicine at Mount Sinai in New York have identified and described a previously unknown ...