Figure 1: Structure of arrested Pol II. Figure 2: Backtracked RNA in the backtrack site. The presented structural snapshots of transcription intermediates reveal the mechanisms of Pol II backtracking, ...

Backtracking refers to the retrograde movement of the RNA-dependent RNA polymerase (RdRp), which is the crucial enzyme within the SARS-CoV-2 replication-transcription complex. This enzyme comprises ...